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Pons, JL; Tornero, J; Akay, M (Ed.)Free, publicly-accessible full text available January 1, 2026
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Williamson, Jordan N; James, Shirley A; He, Dorothy; Peng, Rita Huan-Ting; Mulyana, Beni; Yang, Yuan (, IEEE)
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He, Dorothy; Sikora, William A; James, Shirley A; Williamson, Jordan N; Lepak, Louis V; Cheema, Carolyn F; Sidorov, Evgeny; Li, Sheng; Yang, Yuan (, American Journal of Physical Medicine & Rehabilitation)ObjectiveThis quasi-experimental study examined the effect of repetitive finger stimulation on brain activation in eight stroke and seven control subjects, measured by quantitative electroencephalogram. MethodsWe applied 5 mins of 2-Hz repetitive bilateral index finger transcutaneous electrical nerve stimulation and compared differences pre– and post–transcutaneous electrical nerve stimulation using quantitative electroencephalogram metrics delta/alpha ratio and delta-theta/alpha-beta ratio. ResultsBetween-group differences before and after stimulation were significantly different in the delta/alpha ratio (z= −2.88,P= 0.0040) and the delta-theta/alpha-beta ratio variables (z= −3.90 withP< 0.0001). Significant decrease in the delta/alpha ratio and delta-theta/alpha-beta ratio variables after the transcutaneous electrical nerve stimulation was detected only in the stroke group (delta/alpha ratio diff = 3.87,P= 0.0211) (delta-theta/alpha-beta ratio diff = 1.19,P= 0.0074). ConclusionsThe decrease in quantitative electroencephalogram metrics in the stroke group may indicate improved brain activity after transcutaneous electrical nerve stimulation. This finding may pave the way for a future novel therapy based on transcutaneous electrical nerve stimulation and quantitative electroencephalogram measures to improve brain recovery after stroke.more » « less
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